![]() Received: NovemAccepted: DecemPublished: January 15, 2016Ĭopyright: © 2016 Boccaccio et al. PLoS ONE 11(1):Įditor: Jie Zheng, University of Akron, UNITED STATES Although experimental data is still necessary to properly relate the mechanical/biological environment to the scaffold microstructure, this model represents an important step towards optimizing geometry of functionally graded scaffolds based on mechanobiological criteria.Ĭitation: Boccaccio A, Uva AE, Fiorentino M, Mori G, Monno G (2016) Geometry Design Optimization of Functionally Graded Scaffolds for Bone Tissue Engineering: A Mechanobiological Approach. For a pure shear loading, instead, FGSs allow to significantly increase the bone formation compared to a homogeneous porosity scaffolds. For a pure compression loading, it was found that the pore dimensions are almost constant throughout the entire scaffold and using a FGS allows the formation of amounts of bone slightly larger than those obtainable with a homogeneous porosity scaffold. The results show that the loading conditions affect significantly the optimal porosity distribution. For each combination of these variables, the explicit equation of the porosity distribution law–i.e the law that describes the pore dimensions in function of the spatial coordinates–was determined that allows the highest amounts of bone to be generated. We tested different porosity distribution laws, loading conditions and scaffold Young’s modulus values. the geometry that allows the amount of bone formation to be maximized. For assigned boundary and loading conditions, the algorithm builds iteratively different scaffold geometry configurations with different porosity distributions until the best microstructure geometry is reached, i.e. The algorithm combines the parametric finite element model of a FGS, a computational mechano-regulation model and a numerical optimization routine. ![]() In this study we attempt to bridge the gap by developing a mechanobiology-based optimization algorithm aimed to determine the optimal graded porosity distribution in FGSs. In spite of their wide use in bone tissue engineering, possible models that relate the scaffold gradient to the mechanical and biological requirements for the regeneration of the bony tissue are currently missing. Functionally Graded Scaffolds (FGSs) are porous biomaterials where porosity changes in space with a specific gradient.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |